USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P04083 USC-OGP 2-DE database:  P04083 P04083 General information about the entry View entry in simple text format Entry name ANXA1_HUMAN Primary accession number P04083 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Annexin A1; AltName: Full=Annexin I; AltName: Full=Annexin-1; AltName: Full=Calpactin II; AltName: Full=Calpactin-2; AltName: Full=Chromobindin-9; AltName: Full=Lipocortin I {ECO:0000303|PubMed:1832554}; AltName: Full=Phospholipase A2 inhibitory protein; AltName: Full=p35;. Gene name Name=ANXA1 Synonyms=ANX1, LPC1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1220: pI=6.56; Mw=36056 SPOT OGP-1239: pI=6.05; Mw=32675 SPOT OGP-1247: pI=5.77; Mw=31502 Cross-references UniProtKB/Swiss-Prot P04083; ANXA1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ANXA1_HUMAN Primary accession number P04083 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 217) Name and origin of the protein Description RecName: Full=Annexin A1; AltName: Full=Annexin I; AltName: Full=Annexin-1; AltName: Full=Calpactin II; AltName: Full=Calpactin-2; AltName: Full=Chromobindin-9; AltName: Full=Lipocortin I {ECO:0000303|PubMed:1832554}; AltName: Full=Phospholipase A2 inhibitory protein; AltName: Full=p35; Gene name Name=ANXA1 Synonyms=ANX1, LPC1 Encoded on Name=ANXA1; Synonyms=ANX1, LPC1 Keywords 3D-structure; Acetylation; Adaptive immunity; Annexin; Calcium; Calcium/phospholipid-binding; Cell membrane; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Endosome; Immunity; Inflammatory response; Innate immunity; Isopeptide bond; Membrane; Metal-binding; Nucleus; Pharmaceutical; Phospholipase A2 inhibitor; Phosphoprotein; Reference proteome; Repeat; Secreted; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X05908; CAA29338.1; -; mRNA EMBL BC001275; AAH01275.1; -; mRNA EMBL BC035993; AAH35993.1; -; mRNA CCDS CCDS6645.1; -; . PIR A03080; LUHU; . RefSeq NP_000691.1; NM_000700.2; . RefSeq XP_011516911.1; XM_011518609.1; . UniGene Hs.494173; -; . PDB 1AIN; X-ray; 2.50 A; A=33-346 PDB 1BO9; NMR; -; A=41-113 PDB 1QLS; X-ray; 2.30 A; D=2-12 PDBsum 1AIN; -; . PDBsum 1BO9; -; . PDBsum 1QLS; -; . ProteinModelPortal P04083; -; . SMR P04083; -; . BioGrid 106798; 89; . DIP DIP-32875N; -; . IntAct P04083; 74; . MINT MINT-1212274; -; . STRING 9606.ENSP00000257497; -; . DrugBank DB00288; Amcinonide; . DrugBank DB01234; Dexamethasone; . DrugBank DB00741; Hydrocortisone; . TCDB 1.A.31.1.3; the annexin (annexin) family; . iPTMnet P04083; -; . PhosphoSitePlus P04083; -; . SwissPalm P04083; -; . BioMuta ANXA1; -; . DMDM 113944; -; . DOSAC-COBS-2DPAGE P04083; -; . REPRODUCTION-2DPAGE IPI00218918; -; . REPRODUCTION-2DPAGE P04083; -; . UCD-2DPAGE P04083; -; . EPD P04083; -; . PaxDb P04083; -; . PeptideAtlas P04083; -; . PRIDE P04083; -; . DNASU 301; -; . Ensembl ENST00000257497; ENSP00000257497; ENSG00000135046; . Ensembl ENST00000376911; ENSP00000366109; ENSG00000135046; . GeneID 301; -; . KEGG hsa:301; -; . CTD 301; -; . DisGeNET 301; -; . GeneCards ANXA1; -; . HGNC HGNC:533; ANXA1; . HPA CAB013023; -; . HPA CAB035987; -; . HPA CAB058693; -; . HPA HPA011271; -; . HPA HPA011272; -; . MIM 151690; gene; . neXtProt NX_P04083; -; . OpenTargets ENSG00000135046; -; . PharmGKB PA24823; -; . eggNOG KOG0819; Eukaryota; . eggNOG ENOG410XPUN; LUCA; . GeneTree ENSGT00760000118972; -; . HOGENOM HOG000158803; -; . HOVERGEN HBG061815; -; . InParanoid P04083; -; . KO K17091; -; . OMA IMVSRHE; -; . OrthoDB EOG091G0H6H; -; . PhylomeDB P04083; -; . TreeFam TF105452; -; . Reactome R-HSA-416476; G alpha (q) signalling events; . Reactome R-HSA-418594; G alpha (i) signalling events; . Reactome R-HSA-444473; Formyl peptide receptors bind formyl peptides and many other ligands; . Reactome R-HSA-445355; Smooth Muscle Contraction; . Reactome R-HSA-6785807; Interleukin-4 and 13 signaling; . SignaLink P04083; -; . SIGNOR P04083; -; . ChiTaRS ANXA1; human; . EvolutionaryTrace P04083; -; . GeneWiki Annexin_A1; -; . GenomeRNAi 301; -; . PRO PR:P04083; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000135046; -; . CleanEx HS_ANXA1; -; . ExpressionAtlas P04083; baseline and differential; . Genevisible P04083; HS; . GO GO:0016324; C:apical plasma membrane; ISS:UniProtKB; . GO GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0009986; C:cell surface; IDA:BHF-UCL; . GO GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL; . GO GO:0001533; C:cornified envelope; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0031901; C:early endosome membrane; ISS:UniProtKB; . GO GO:0005768; C:endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0031313; C:extrinsic component of endosome membrane; ISS:UniProtKB; . GO GO:0031232; C:extrinsic component of external side of plasma membrane; IDA:UniProtKB; . GO GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0016328; C:lateral plasma membrane; ISS:UniProtKB; . GO GO:0042629; C:mast cell granule; IEA:Ensembl; . GO GO:0031966; C:mitochondrial membrane; IEA:Ensembl; . GO GO:0031514; C:motile cilium; ISS:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:BHF-UCL; . GO GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0043234; C:protein complex; IEA:Ensembl; . GO GO:0042383; C:sarcolemma; IEA:Ensembl; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0036310; F:annealing helicase activity; IEA:Ensembl; . GO GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; ISS:UniProtKB; . GO GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB; . GO GO:0048306; F:calcium-dependent protein binding; IPI:AgBase; . GO GO:0033676; F:double-stranded DNA-dependent ATPase activity; IEA:Ensembl; . GO GO:0004386; F:helicase activity; IEA:Ensembl; . GO GO:0019834; F:phospholipase A2 inhibitor activity; IDA:UniProtKB; . GO GO:0005543; F:phospholipid binding; TAS:ProtInc; . GO GO:0030674; F:protein binding; bridging; IDA:UniProtKB GO GO:0005102; F:receptor binding; TAS:ProtInc; . GO GO:0003697; F:single-stranded DNA binding; IEA:Ensembl; . GO GO:0003727; F:single-stranded RNA binding; IEA:Ensembl; . GO GO:0005198; F:structural molecule activity; IDA:UniProtKB; . GO GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB; . GO GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW; . GO GO:0046632; P:alpha-beta T cell differentiation; ISS:BHF-UCL; . GO GO:0050482; P:arachidonic acid secretion; IEA:Ensembl; . GO GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc; . GO GO:0071385; P:cellular response to glucocorticoid stimulus; IDA:BHF-UCL; . GO GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl; . GO GO:0032508; P:DNA duplex unwinding; IEA:Ensembl; . GO GO:0036292; P:DNA rewinding; IEA:Ensembl; . GO GO:0031018; P:endocrine pancreas development; IEA:Ensembl; . GO GO:0044849; P:estrous cycle; IEA:Ensembl; . GO GO:0007187; P:G-protein coupled receptor signaling pathway; coupled to cyclic nucleotide second messenger; IDA:UniProtKB GO GO:0042063; P:gliogenesis; IEA:Ensembl; . GO GO:0071621; P:granulocyte chemotaxis; IDA:UniProtKB; . GO GO:0070365; P:hepatocyte differentiation; IEA:Ensembl; . GO GO:0006954; P:inflammatory response; ISS:UniProtKB; . GO GO:0045087; P:innate immune response; IEA:UniProtKB-KW; . GO GO:0030073; P:insulin secretion; IEA:Ensembl; . GO GO:0030216; P:keratinocyte differentiation; IDA:UniProtKB; . GO GO:0002548; P:monocyte chemotaxis; IDA:UniProtKB; . GO GO:0014839; P:myoblast migration involved in skeletal muscle regeneration; IEA:Ensembl; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB; . GO GO:2000483; P:negative regulation of interleukin-8 secretion; IMP:BHF-UCL; . GO GO:1900138; P:negative regulation of phospholipase A2 activity; IEA:Ensembl; . GO GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IDA:UniProtKB; . GO GO:0097350; P:neutrophil clearance; IMP:BHF-UCL; . GO GO:0001780; P:neutrophil homeostasis; IMP:BHF-UCL; . GO GO:0018149; P:peptide cross-linking; IDA:UniProtKB; . GO GO:0006909; P:phagocytosis; ISS:UniProtKB; . GO GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl; . GO GO:0032743; P:positive regulation of interleukin-2 production; IDA:UniProtKB; . GO GO:0033031; P:positive regulation of neutrophil apoptotic process; IEA:Ensembl; . GO GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Ensembl; . GO GO:0042102; P:positive regulation of T cell proliferation; IDA:UniProtKB; . GO GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IDA:UniProtKB; . GO GO:0031340; P:positive regulation of vesicle fusion; IDA:UniProtKB; . GO GO:0090303; P:positive regulation of wound healing; IDA:UniProtKB; . GO GO:0070459; P:prolactin secretion; IEA:Ensembl; . GO GO:0030850; P:prostate gland development; IEA:Ensembl; . GO GO:0008360; P:regulation of cell shape; IDA:UniProtKB; . GO GO:0046883; P:regulation of hormone secretion; IMP:UniProtKB; . GO GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB; . GO GO:0032652; P:regulation of interleukin-1 production; ISS:UniProtKB; . GO GO:0002685; P:regulation of leukocyte migration; ISS:UniProtKB; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0032355; P:response to estradiol; IEA:Ensembl; . GO GO:0070555; P:response to interleukin-1; IEA:Ensembl; . GO GO:0043434; P:response to peptide hormone; IEA:Ensembl; . GO GO:0010165; P:response to X-ray; IEA:Ensembl; . GO GO:0007165; P:signal transduction; TAS:UniProtKB; . Gene3D 1.10.220.10; -; 4; . InterPro IPR001464; Annexin; . InterPro IPR018502; Annexin_repeat; . InterPro IPR018252; Annexin_repeat_CS; . InterPro IPR002388; ANX1; . PANTHER PTHR10502:SF141; PTHR10502:SF141; 1; . Pfam PF00191; Annexin; 4; . PRINTS PR00196; ANNEXIN; . PRINTS PR00197; ANNEXINI; . SMART SM00335; ANX; 4; . PROSITE PS00223; ANNEXIN; 4; .

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